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Seth Donoughe

Graduate Student


I was captivated by the complexity in biological systems when I was an undergraduate at Swarthmore College. While there, I studied dragonfly wing structure with Rachel Merz and anemone behavior with Liz Vallen. After graduating, I worked in the lab of Steve DiNardo at the University of Pennsylvania School of Medicine, where I was given the opportunity to shift my focus to Drosophila developmental genetics. There, my research centered on how planar polarity is established in a growing fly. In the Extavour Lab, I hope to explore early insect development, with the goal of uncovering a little bit more about how different groups have evolved.

I was a graduate student in the OEB program, and held a National Science Foundation Graduate Research Fellowship.

After defening my PhD thesis in 2018, I moved to the University of Chicago to pursue postdoctoral work with Sally Horne-Badovinac and Ed Munro. I was awarded a Chicago Fellowship and a Jane Coffin Childs Postdoctoral Fellowship to support this work.


Church SH, Donoughe SD, de Medeiros BAS and Extavour CG. A dataset of egg size and shape from more than 6,700 insect species. Scientific Data (in press) (2019)

Church SH, Donoughe SD, de Medeiros BAS and Extavour CG. Insect egg size and shape evolve with ecology, not developmental rate. bioRxiv 471946 (2018)

Donoughe, S.D., Kim, C. and Extavour, C.G. High-throughout live-imaging of embryos in microwell arrays using a module, inexpensive specimen mounting system. Biology Open 7(7) pii: bio.031260 (2018)

Donoughe, S. and Extavour, C.G. Embryonic development of the cricket Gryllus bimaculatus. Developmental Biology 411(1): 140-156 (2015).

Donoughe, S., Nakamura, T., Ewen-Campen, B., Green II, D.A., Henderson, L. and Extavour, C.G. BMP signalling is required for generation of primordial germ cells in an insect. Proceedings of the National Academy of Sciences of the USA 111(11): 4133-4138 (2014).

Ewen-Campen, B., Donoughe, S., Clarke, D.N., and Extavour, C.G. Germ cell specification requires zygotic mechanisms rather than germ plasm in a basally branching insect. Current Biology doi 10.1016/j.cub.2013.03.063, Epub 25 April (2013).

Resilin in dragonfly and damselfly wings and its implications for wing flexibility. Donoughe, S., Crall, J.D., Merz, R.A. and Combes, S.A. Journal of Morphology 272(12):1409-21 (2011).

dachsous and frizzled contribute separately to planar polarity in the Drosophila ventral epidermisDonoughe, S. and DiNardo, S.  Development 138: 2751-9 (2011).